4. For patients with PCV at or below 15%, transfuse Packed Red Blood Cells in saline at 3-5 ml per pound given once or twice daily. The packed cells can also be given sequentially or mixed with Fresh-Frozen Plasma and transfused as reconstituted whole blood (see Product Inserts for detailed options).
5. Avoid drugs or biologics that impair hemostasis and/or induce  thrombocytopenia.                                               

These include:

• aspirin
• ormetoprim - sulfonamide
• estrogens
• phenylbutazone
• furacin
• promazine tranquilizers
• heparin
• trimethoprim - sulfonamides
• modified-live virus vaccines
• warfarin
• For special situations, cryoconcentrated plasma (Cryoprecipitate)     can be provided.   Call for product information.

 Rodenticide Toxicosis (Vitamin K Deficiency)
1. Identify toxicant and manage case to induce vomiting as indicated.

2. Use vitamin K1 by subcutaneous, intramuscular, or oral routes at 1 mg per pound body weight once or twice daily for 7-10 days; taper dosage gradually each week over the next 30 days depending on the potency and half-life of the rodenticide involved. (When in doubt, assume that toxin is one of the. long-acting, more potent compounds). Do not give vitamin K by intravenous route as anaphylaxis can occur. Several hours are required to correct the coagulopathy once vitamin K is incorporated into synthesis of prothrombin complex coagulation factors.

3. Transfuse Fresh-Frozen Plasma at 3-5 ml per pound of body weight once or twice daily.

4. For patients with PCV at or below 15%, transfuse Packed Red Blood Cells along with Fresh-Frozen Plasma, each to be given at 3-5 ml per pound once or twice daily, either sequentially, or after premixing to reconstitute as whole blood (see Product Inserts for additional details).